Ezatiostat hydrochloride
CAS No. 286942-97-0
Ezatiostat hydrochloride ( TER199; TLK199 HCl )
产品货号. M27628 CAS No. 286942-97-0
Ezatiostat hydrochloride is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatment of cytopenias.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥429 | 有现货 |
|
5MG | ¥608 | 有现货 |
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10MG | ¥996 | 有现货 |
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25MG | ¥1709 | 有现货 |
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50MG | ¥2616 | 有现货 |
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100MG | ¥4415 | 有现货 |
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200MG | ¥6618 | 有现货 |
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500MG | ¥9939 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Ezatiostat hydrochloride
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Ezatiostat hydrochloride is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatment of cytopenias.
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产品描述Ezatiostat hydrochloride is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatment of cytopenias. In addition, Ezatiostat hydrochloride has been revealed to selectively bind to and thus inhibit GSTP1-1.(In Vitro):Because GST P1-1 can bind to and inhibit JNK, Ezatiostat hydrochloride has also been exhibited to inhibit GST P1-1, activate JNK, and promote the growth and maturation of hematopoietic progenitors in preclinical models. Moreover, Ezatiostat hydrochloride has been reported to stimulate the proliferation of myeloid precursors. Ezatiostat hydrochloride has been elucidated to induce growth inhibition and cellular apoptosis in human leukemia cells (CC50: 6-17μM). Apart from these, Ezatiostat hydrochloride has shown the stimulation of multilineage differentiation in mature monocytes, granulocytes, and erythrocytes .(In Vivo):Administration of Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation only in glutathione S-transferase P1-1 (GSTP1+/+) and not in GSTP1-/- animals.
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同义词TER199; TLK199 HCl
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number286942-97-0
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分子量566.1
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分子式C27H36ClN3O6S
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纯度>98% (HPLC)
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溶解度——
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SMILESCl.CCOC(=O)C(N)CCC(=O)NC(CSCc1ccccc1)C(=O)NC(C(=O)OCC)c1ccccc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Wang Z , Huang J , Zhou S , et al. Anemonin attenuates osteoarthritis progression through inhibiting the activation of IL-1β/NF-κB pathway[J]. Journal of Cellular and Molecular Medicine, 2017.
产品手册
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