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Ezatiostat hydrochloride

CAS No. 286942-97-0

Ezatiostat hydrochloride ( TER199 | TLK199 HCl )

产品货号. M27628 CAS No. 286942-97-0

Ezatiostat 盐酸盐是一种有效的谷胱甘肽 S-转移酶抑制剂。 Ezatiostat 盐酸盐是一种新型谷胱甘肽类似物,是治疗血细胞减少症的潜在化合物。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥429 有现货
5MG ¥608 有现货
10MG ¥996 有现货
25MG ¥1709 有现货
50MG ¥2616 有现货
100MG ¥4415 有现货
200MG ¥6618 有现货
500MG ¥9939 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Ezatiostat hydrochloride
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Ezatiostat 盐酸盐是一种有效的谷胱甘肽 S-转移酶抑制剂。 Ezatiostat 盐酸盐是一种新型谷胱甘肽类似物,是治疗血细胞减少症的潜在化合物。
  • 产品描述
    Ezatiostat hydrochloride is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatment of cytopenias. In addition, Ezatiostat hydrochloride has been revealed to selectively bind to and thus inhibit GSTP1-1.(In Vitro):Because GST P1-1 can bind to and inhibit JNK, Ezatiostat hydrochloride has also been exhibited to inhibit GST P1-1, activate JNK, and promote the growth and maturation of hematopoietic progenitors in preclinical models. Moreover, Ezatiostat hydrochloride has been reported to stimulate the proliferation of myeloid precursors. Ezatiostat hydrochloride has been elucidated to induce growth inhibition and cellular apoptosis in human leukemia cells (CC50: 6-17μM). Apart from these, Ezatiostat hydrochloride has shown the stimulation of multilineage differentiation in mature monocytes, granulocytes, and erythrocytes .(In Vivo):Administration of Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation only in glutathione S-transferase P1-1 (GSTP1+/+) and not in GSTP1-/- animals.
  • 体外实验
    Ezatiostat causes dissociation of the enzyme from the jun-N-terminal kinase/c-Jun (JNK/JUN) complex, leading to JNK activation by phosphorylation. The therapeutic action of ezatiostat appears to include both proliferation of normal myeloid progenitors as well as apoptosis of the malignant clone.Selection of a resistant clone of an HL60 tumor cell line through chronic exposure to Ezatiostat (TLK199) results in cells with elevated activities of c-Jun NH2 terminal kinase (JNK1) and ERK1/ERK2, and allowes the cells to proliferate under stress conditions that induced high levels of apoptosis in the wild type cells.
  • 体内实验
    Administration of Ezatiostat (TLK199), stimulates both lymphocyte production and bone marrow progenitor (colony-forming unit-granulocyte macrophage) proliferation, but only in glutathione S-transferase P1-1 (GSTP1+/+) and not in GSTP1-/- animals.
  • 同义词
    TER199 | TLK199 HCl
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    ——
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    286942-97-0
  • 分子量
    566.11
  • 分子式
    C27H36ClN3O6S
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    Cl.CCOC(=O)C(N)CCC(=O)NC(CSCc1ccccc1)C(=O)NC(C(=O)OCC)c1ccccc1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Wang Z , Huang J , Zhou S , et al. Anemonin attenuates osteoarthritis progression through inhibiting the activation of IL-1β/NF-κB pathway[J]. Journal of Cellular and Molecular Medicine, 2017.
产品手册
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