
Ezatiostat hydrochloride
CAS No. 286942-97-0
Ezatiostat hydrochloride ( TER199 | TLK199 HCl )
产品货号. M27628 CAS No. 286942-97-0
Ezatiostat 盐酸盐是一种有效的谷胱甘肽 S-转移酶抑制剂。 Ezatiostat 盐酸盐是一种新型谷胱甘肽类似物,是治疗血细胞减少症的潜在化合物。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥429 | 有现货 |
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5MG | ¥608 | 有现货 |
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10MG | ¥996 | 有现货 |
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25MG | ¥1709 | 有现货 |
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50MG | ¥2616 | 有现货 |
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100MG | ¥4415 | 有现货 |
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200MG | ¥6618 | 有现货 |
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500MG | ¥9939 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Ezatiostat hydrochloride
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Ezatiostat 盐酸盐是一种有效的谷胱甘肽 S-转移酶抑制剂。 Ezatiostat 盐酸盐是一种新型谷胱甘肽类似物,是治疗血细胞减少症的潜在化合物。
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产品描述Ezatiostat hydrochloride is an effective inhibitor of glutathione S-transferase. Ezatiostat hydrochloride is a novel glutathione analog and the potential treatment of cytopenias. In addition, Ezatiostat hydrochloride has been revealed to selectively bind to and thus inhibit GSTP1-1.(In Vitro):Because GST P1-1 can bind to and inhibit JNK, Ezatiostat hydrochloride has also been exhibited to inhibit GST P1-1, activate JNK, and promote the growth and maturation of hematopoietic progenitors in preclinical models. Moreover, Ezatiostat hydrochloride has been reported to stimulate the proliferation of myeloid precursors. Ezatiostat hydrochloride has been elucidated to induce growth inhibition and cellular apoptosis in human leukemia cells (CC50: 6-17μM). Apart from these, Ezatiostat hydrochloride has shown the stimulation of multilineage differentiation in mature monocytes, granulocytes, and erythrocytes .(In Vivo):Administration of Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation only in glutathione S-transferase P1-1 (GSTP1+/+) and not in GSTP1-/- animals.
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体外实验Ezatiostat causes dissociation of the enzyme from the jun-N-terminal kinase/c-Jun (JNK/JUN) complex, leading to JNK activation by phosphorylation. The therapeutic action of ezatiostat appears to include both proliferation of normal myeloid progenitors as well as apoptosis of the malignant clone.Selection of a resistant clone of an HL60 tumor cell line through chronic exposure to Ezatiostat (TLK199) results in cells with elevated activities of c-Jun NH2 terminal kinase (JNK1) and ERK1/ERK2, and allowes the cells to proliferate under stress conditions that induced high levels of apoptosis in the wild type cells.
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体内实验Administration of Ezatiostat (TLK199), stimulates both lymphocyte production and bone marrow progenitor (colony-forming unit-granulocyte macrophage) proliferation, but only in glutathione S-transferase P1-1 (GSTP1+/+) and not in GSTP1-/- animals.
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同义词TER199 | TLK199 HCl
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number286942-97-0
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分子量566.11
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分子式C27H36ClN3O6S
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纯度>98% (HPLC)
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溶解度——
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SMILESCl.CCOC(=O)C(N)CCC(=O)NC(CSCc1ccccc1)C(=O)NC(C(=O)OCC)c1ccccc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Wang Z , Huang J , Zhou S , et al. Anemonin attenuates osteoarthritis progression through inhibiting the activation of IL-1β/NF-κB pathway[J]. Journal of Cellular and Molecular Medicine, 2017.
产品手册




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